基本信息:
- 专利标题： Blood-pressure lowering piperazine derivatives
- 专利标题（中）：Blutdruck herabsetzende Piperazin-Derivate。
- 申请号：EP84201477.1 申请日：1984-10-15
- 公开(公告)号：EP0138280A2 公开(公告)日：1985-04-24
- 发明人： Hartog, Jan , Wouters, Wouter , van Wijngaarden, Ineke
- 申请人： DUPHAR INTERNATIONAL RESEARCH B.V
- 申请人地址： C.J. van Houtenlaan 36 NL-1381 CP Weesp NL
- 专利权人： DUPHAR INTERNATIONAL RESEARCH B.V
- 当前专利权人： DUPHAR INTERNATIONAL RESEARCH B.V
- 当前专利权人地址： C.J. van Houtenlaan 36 NL-1381 CP Weesp NL
- 代理机构： Muis, Maarten
- 优先权： NL8303569 19831017
- 主分类号： C07D241/42
- IPC分类号： C07D241/42 ; C07D235/06 ; C07D209/18 ; C07D319/18 ; C07D215/40 ; C07D317/06 ; C07D321/00 ; C07D319/08 ; C07D249/18 ; C07D311/58 ; C07D307/79
摘要：
The invention relates to new piperazine derivatives of the formula
wherein A is an optionally substituted bicyclic hetero aryl radical, n has the value 1 or 2, R, and R 2 are hydrogen or alkyl (1-3 C). A is -CH 2 -CH 2 - or -CH(CH 3 )-CH 2 - and B is an optionally substituted aryl or hetero aryl group, an alkyl group or a saturated or partly unsaturated cycloalkyl group and salts and products thereof. These new compounds are useful for the treatment of circulatory diseases. In particular it has has been found that these compounds have blood-pressure lowering properties regulated by a central mechanism of action.
The invention also relates to new intermediates useful for the preparation of piperazine compounds of the above formula (1)
摘要（中）：
wherein A is an optionally substituted bicyclic hetero aryl radical, n has the value 1 or 2, R, and R 2 are hydrogen or alkyl (1-3 C). A is -CH 2 -CH 2 - or -CH(CH 3 )-CH 2 - and B is an optionally substituted aryl or hetero aryl group, an alkyl group or a saturated or partly unsaturated cycloalkyl group and salts and products thereof. These new compounds are useful for the treatment of circulatory diseases. In particular it has has been found that these compounds have blood-pressure lowering properties regulated by a central mechanism of action.
The invention also relates to new intermediates useful for the preparation of piperazine compounds of the above formula (1)
本发明涉及式...的新的哌嗪衍生物，其中A为任选取代的双环杂芳基，n为1或2，R 1和R 2为氢或烷基（1-3C）。 -CH 2 -CH 2 - 或-CH（CH 3）-CH 2 - 并且B是任选取代的芳基或杂芳基，烷基或饱和或部分不饱和环烷基及其盐和产物。 这些新化合物可用于治疗循环系统疾病。 特别地，已经发现这些化合物具有由中枢作用机制调节的降血压特性。 本发明还涉及可用于制备上述式（1）的哌嗪化合物的新中间体。
公开/授权文献:
- EP0138280B1 Blood-pressure lowering piperazine derivatives 公开/授权日：1988-06-08
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D241/00 | 杂环化合物，含1,4-二嗪环或氢化1,4-二嗪环 |
| --------C07D241/02 | .不与其他环稠合 |
| ----------C07D241/38 | ..只有氢或碳原子直接连在环氮原子上 |
| ------------C07D241/40 | ...苯并吡嗪 |
| --------------C07D241/42 | ....只有氢原子、烃基或取代的烃基，直接连在杂环的碳原子上 |