发明公开
EP0013000A3 Polymeric agent for releasing 5-aminosalicylic acid or its derivatives into the gastrointestinal tract, pharmaceutical formulation comprising said agent,method of its preparation and method of preparing said formulation
失效
基本信息:
- 专利标题： Polymeric agent for releasing 5-aminosalicylic acid or its derivatives into the gastrointestinal tract, pharmaceutical formulation comprising said agent,method of its preparation and method of preparing said formulation
- 专利标题（中）：用于将5-氨基苯甲酸或其衍生物释放到胃肠道药物中的聚合物，包含所述药剂的药物制剂，其制备方法和制备所述制剂的方法
- 申请号：EP79105279 申请日：1979-12-19
- 公开(公告)号：EP0013000A3 公开(公告)日：1981-01-21
- 发明人： Parkinson, Thomas M. , Brown, Joseph P. , Wingard, Jr., Robert E.
- 申请人： DYNAPOL
- 专利权人： DYNAPOL
- 当前专利权人： DYNAPOL
- 优先权： US971609 19781220; US95411 19791129
- 主分类号： A61K31/745
- IPC分类号： A61K31/745 ; A61K31/785 ; A61K31/795 ; A61K09/18
摘要：
An intestinal anti-inflammatory preparation comprising a polymeric agent for releasing 5-aminosalicylic acid or its salts is disclosed. The polymeric agent comprises a nonabsorbable pharmacologically acceptable organic polymer backbone containing aromatic rings to which are covalently bonded via azo bonds a plurality of salicylic acid or salicylate's salt groups. The azo bonds attach to the salicylates' 5-position carbon. The polymers' azo bonds undergo bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid and/or its salts.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/70 | .碳水化合物；糖；其衍生物 |
| ----------A61K31/745 | ..烃类聚合物 |