基本信息:
- 专利标题: INHIBIDORES DE TRANSFERASA DE PROTEINA FARNESILO
- 申请号:CO99078843 申请日:1999-12-16
- 公开(公告)号:CO5160350A1 公开(公告)日:2002-05-30
- 发明人: TAVERAS ARTHUR G , DOLL RONALD J , COOPER ALAN B , FERREIRA JOHAN A , GUZI TIMOTHY , MALLAMS ALAN K , RANE DINANATH F , RANE VIYYOOR M GIRIJAVALLAB , AFONSO ADRIANO , AKI J CYNTHIA , JIANPING CHAO , ALVAREZ CARMEN , KELLY JOSEPH M , TARIK LALWANI , JAGDISH A DESAI , WANG JAMES J-S , WEINSTEIN JAY
- 申请人: SCHERING CORP
- 专利权人: SCHERING CORP
- 当前专利权人: SCHERING CORP
- 优先权: US21639898 1998-12-18
- 主分类号: A61K31/15
- IPC分类号: A61K31/15 ; A61K31/165 ; A61K31/496 ; A61P35/00 ; A61P35/02 ; A61P43/00 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D521/00
Disclosed are compounds of formula (1.0) wherein R<13> represents an imidazole ring; R<14> represents a carbamate, urea, amide or sulfonamide group; R<8> represents H when the alkyl chain between the amide group and the R<13> imidazole group is substituted, or R<8> represents a substituent such aa arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R<8> is H, and the alkyl chain between the amide group and the R<13> imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.