The utility model relates to the field of medical detection experiment devices. The EP tube cap opener comprises a cap body, including a handle, the handle is of an inverted-T-shaped structure with anopening in the lower side. Two hinge rods are hinged to the inner side wall of the handle; the other ends of the two hinge rods are hinged to the same mounting plate; wherein the two hinge rods are arranged in parallel, the parallel hinge rods can enable the mounting plate to be always kept in a vertical state during rotation, the mounting plate is of a long-strip-shaped structure, the sides, close to each other, of the two mounting plates are fixedly connected with rubber non-slip mats, and a plurality of grooves are formed in the upper side face of the mounting plate at equal intervals. Byarranging the handle, the hinge rod, the mounting plate and the rubber non-slip mat, the EP pipe can be clamped by the rubber non-slip mat when the cover is opened, the EP pipe is prevented from shaking when the cover is opened, and therefore liquid of the EP pipe is prevented from being scattered.