The utility model discloses a five-prevention locking device which is characterized by comprising a five-prevention lock and an electronic key. The five-prevention lock comprises a lock bolt assembly, an electromagnetic lock control assembly and a code reader. The electromagnetic lock control assembly and the code reader are arranged in a lock body of the lock bolt assembly. The code reader controls a circuit of the electromagnetic lock control assembly to be connected or disconnected. The electromagnetic lock control assembly controls the lock bolt assembly to be opened or closed. The electronic key is provided with a radio frequency chip matched with the code reader in a mutual recognizing mode. According to the five-prevention locking device, unlocking is carried out through the correlation and recognition functions instead of inserting the key into a lock hole; as the lock hole is omitted, on one hand, lock hole blocking or key breaking is effectively prevented, or the situation that due to lock rusting, unlocking is difficult or consumes too much time is avoided; on the other hand, the possibility that tools like a screwdriver is adopted for unlocking the five-prevention lock in a forced mode is eradicated, and therefore a five-prevention system is safer and more stable.