The utility model relates to a 10kV multi-use drainage wire insulating holder comprising a clamp, an insulating outer cylinder, a clamp driving mechanism, a fixed locking mechanism and an insulating handle. The insulating material for making the 10kV multi-use drainage wire insulating holder body is formed by compounding, pressurizing and integrally winding epoxy resin and alkali-free glass fibers. The clamp is open in a normal state. By adoption of the device and by use of an insulating rod and insulating gloves, an operator can climb the rod or take an aerial lift device with an insulating arm to carry out lead disconnection and connection on a 10kV overhead line in a live state. The 10kV multi-use drainage wire insulating holder has the characteristics of high insulation performance and high intensity. The clamp can stably control wires of different types. An operator can firmly control a drainage wire, and can prevent the drainage wire from swinging to cause grounding or short-circuit fault and ensure operation safety. The 10kV multi-use drainage wire insulating holder can greatly improve the safety in the process of live lead disconnection and connection, has a wide range of applications, and has distinctive practical features.