The utility model discloses a negative pressure drainage device which comprises a negative liquid collection cavity with a liquid inlet and a liquid outlet. The liquid inlet with an upper cover is arranged on the upper top face of the negative liquid collection cavity body and the liquid outlet is arranged on the lower bottom face of the negative liquid collection cavity body. A blocking cover is arranged at the liquid outlet. A compression spring is arranged in the negative pressure liquid collection cavity body. A pressure indicator scale is fixedly arranged at one side of the bottom face of the negative liquid collection cavity body. A ring buckle which stretches out of the upper top face of the negative pressure liquid collection cavity body is movably sleeved on the pressure indicator scale. A liquid level indicating line is arranged on the outer surface of the negative liquid collection cavity body. The negative pressure drainage device has the advantages that pressure inside the drainage device can be adjusted and the negative pressure drainage device is suitable for both the adult and the child. Meanwhile, when nursing staff clean accumulated liquid in the liquid collection cavity body, a stomach tube and the drainage device do not need separating, the blocking cover can be directly pulled out and gastric juice can be drained instantly. The negative pressure drainage device can be fixed on the bed side of the patient as a whole, convenient to use for the patient who needs drainage and the rate of pipe detachment is reduced.