
基本信息:
- 专利标题: 蛋白酪氨酸磷酸酯酶1B抑制剂1,3-二羟基-5-烷基苯类化合物的制备方法及其用途
- 专利标题(英):Preparation and use of compounds i.e., 1, 3-dihydroxy-5-alkyl benzene as inhbitor of protein-tyrosine-phosphatase 1B
- 申请号:CN200410017589.2 申请日:2004-04-09
- 公开(公告)号:CN1680238A 公开(公告)日:2005-10-12
- 发明人: 郭跃伟 , 王继栋 , 李佳 , 南发俊 , 于嘉陵 , 周秀红
- 申请人: 中国科学院上海药物研究所
- 申请人地址: 上海市浦东张江高科技园区祖冲之路555号
- 专利权人: 中国科学院上海药物研究所
- 当前专利权人: 中国科学院上海药物研究所
- 当前专利权人地址: 上海市浦东张江高科技园区祖冲之路555号
- 代理机构: 上海开祺专利代理有限公司
- 代理人: 费开逵
- 主分类号: C07C39/08
- IPC分类号: C07C39/08 ; C07C37/70 ; A61K31/05 ; A61P3/04 ; A61P3/10 ; A61P5/50
Production of 1,3-dihydroxy-5-alkylamine compound with protein tyrosine phosphatase 1B inhibiting activity extracted and separated from branches and leaves of Lumnitzera racemosa Willd and its use are disclosed. R1 and R2 is H or Ac, R3 is H or CH3, n=8 or 10. It is carried out by drying and breaking branches and leaves of Lumnitzera racemosa, extracting by methyl alcohol, extracting the subsection of light petroleum, acetic ether and (n-)butanol, silica gel column and Sephadex LH-20 gel column chromatographing the part of acetic ether, separating to obtain monomer compound, analyzing by wave spectrum, determining 1,3-dihydroxy-5-alkylamine compound, acetylating and methylating reacting, and obtaining acetylate and methylate. It has PTP1B inhibiting activity and can be used for diabetes mellitus and obesity.
公开/授权文献:
- CN100506769C 蛋白酪氨酸磷酸酯酶1B抑制剂1,3-二羟基-5-烷基苯类化合物的用途 公开/授权日:2009-07-01
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C37/00 | 有羟基或氧—金属基连接在六元芳环碳原子上化合物的制备 |
--------C07C37/64 | .氧—金属基连在六元芳环碳原子上的氧—金属化合物的制备 |
----------C07C39/08 | ..二羟基苯;它们的烷基化衍生物 |