基本信息:
- 专利标题： 一种筛选修复脑神经元退化药物的果蝇疾病模型及其构建方法与应用
- 专利标题（英）：Drosophila disease model for screening drug of restoring cranial nerve cell degeneration and constructing method and application thereof
- 申请号：CN03102234.0 申请日：2003-01-30
- 公开(公告)号：CN1521260A 公开(公告)日：2004-08-18
- 发明人： 谢佐平 , 钟毅 , 陈健
- 申请人： 清华大学 , 北京卓凯生物技术有限公司
- 申请人地址： 北京市海淀区清华大学生物系
- 专利权人： 清华大学,北京卓凯生物技术有限公司
- 当前专利权人： 清华大学,北京卓凯生物技术有限公司
- 当前专利权人地址： 北京市海淀区清华大学生物系
- 代理机构： 北京纪凯知识产权代理有限公司
- 代理人： 关畅
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; A01K67/00 ; G01N33/15
The present invention provides fruit fly disease model for screening medicine of repairing cerebral neure retrogression and its construction method and application. The fruit fly disease model has cerebral neure over expressing human Abeta42 amyloid protein and neure retrogression caused by human A-beta42 amyloid protein mediated nervous toxicity. The fruit fly disease model is the first filial generation fruit fly obtained via crossbreeding between female elav-Ga14 virgin fly and male UAS-Abeta42 fly. Using transgenic fruit fly model in research of human cerebral disease and developing effective medicine has the predominance over other systems. By means of the model and method of the present invention, the screening of great amount of compounds and Chinese herbal medicines may be realized, and the efficient medicine for repairing cerebral neure retrogression may be developed thereby.