The invention discloses a gas-liquid mixing distribution system. The system comprises a shell, and a catalyst grid, a cold hydrogen distributor, a collecting disc, a gas-liquid distributor and a distribution disc which are arranged in the shell from top to bottom; mixing chambers are uniformly arranged on the collecting disc; and the distribution disc is fixedly connected with distribution disc supporting beams and the inner wall of the shell respectively, the gas-liquid distributor is vertically fixed on the distribution disc, gas-liquid spray heads are arranged at the positions, located onthe two sides of the distribution disc supporting beams and the inner wall of the shell, of the distribution disc, the gas-liquid spray heads on the two sides of the distribution disc supporting beamsare oppositely arranged in a staggered mode or obliquely arranged in pairs, and the gas-liquid spray heads on the inner wall of the shell are arranged right opposite to the inner wall of the shell orobliquely opposite to the inner wall of the shell. Cold hydrogen can be more uniformly distributed on the total cross section of a reactor, dead zones on the inner wall of the shell and the distribution disc supporting beams are reduced, and the uniform distribution of gas and liquid on the total cross section of the reactor is fully guaranteed.