基本信息:
- 专利标题： 一种羧酸类化合物还原成醛的方法
- 专利标题（英）：Method for reducing carboxylic acid compound into aldehyde
- 申请号：CN201911113304.8 申请日：2019-11-14
- 公开(公告)号：CN110803984A 公开(公告)日：2020-02-18
- 发明人： 张攀科 , 冯笑甜 , 薄冰 , 王君丽 , 李安文 , 李莹
- 申请人： 郑州大学
- 申请人地址： 河南省郑州市高新区科学大道100号
- 专利权人： 郑州大学
- 当前专利权人： 郑州大学
- 当前专利权人地址： 河南省郑州市高新区科学大道100号
- 代理机构： 郑州优盾知识产权代理有限公司
- 代理人： 张志军
- 主分类号： C07C45/41
- IPC分类号： C07C45/41 ; C07C47/21 ; C07C47/24 ; C07C67/313 ; C07C69/67 ; C07C47/542 ; C07C69/73 ; C07C47/55 ; C07C47/02 ; C07C51/373 ; C07C65/30 ; C07C47/32 ; C07C47/546
The invention discloses a method for reducing a carboxylic acid compound into aldehyde. In a nitrogen atmosphere, in an organic solvent, a ligand/Cu catalyst, the carboxylic acid compound, an anhydride compound and hydrosilane are added by a one-pot method, a reaction is performed under the condition of the temperature of 20-120 DEG C for 2-20 h, after the reaction is completed, quenching and column chromatography separation are performed to obtain the product. The carboxylic acid compound can be successfully converted into aldehyde through one-pot reaction, especially unsaturated carboxylic acid can be reduced, and the reaction yield is generally relatively high. Compared with the prior art, the method has the outstanding advantages that the cheap copper salt is used as a catalyst, so that the experiment cost is greatly reduced. Meanwhile, the used method enlarges the application range of the reaction substrate, improves the compatibility of functional groups, and provides a new synthesis way for reducing the carboxylic acid compound into aldehyde.
公开/授权文献:
- CN110803984B 一种羧酸类化合物还原成醛的方法 公开/授权日：2022-05-06
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C45/00 | 含有CO基，只连接碳或氢原子的化合物的制备；此类化合物的螯合物的制备 |
| --------C07C45/41 | .用羧基或其衍生物的氢解或还原 |