The invention relates to a colchicine compound, a preparation method, a preparation, applications and a pharmaceutical composition thereof, wherein the colchicine compound is amorphous and has a structure represented by a formula I, the X-ray powder diffraction pattern is represented by figure 2, the differential scanning calorimetry analysis curve is represented by figure 3, and the colchicine compound has an exothermic peak at a temperature of about 118.6 DEG C and an has an endothermic peak at a temperature of about 162.4 DEG C. According to the invention, the colchicine has good treatmenteffects on gout, arthritis, tumors, liver fibrosis and pulmonary fibrosis; compared with the products and the technologies in the prior art, the colchicine disclosed by the invention is amorphous, hasadvantages of goof heat resistance, good moisture resistance, stable properties and high bioavailability, and can well meet the requirements of clinical medication; and the preparation method provided by the invention is simple in process, mild in condition, convenient to operate, stable and controllable in quality and suitable for industrial large-scale production.