The invention discloses a regional comprehensive energy system operation state calculation method, and the method comprises the steps: building the following calculation models: a building thermal load model, a heat distribution pipeline model, a coupling equipment model, a power system model, a combined heat and power generation unit model, and a ground source heat pump unit model; and based on the above models, sequentially obtaining the thermal power of load nodes, the operation state result of the thermodynamic system, the operation state result of the combined heat and power generation unit model, the operation state result of the ground source heat pump unit model and the electric power of the nodes, and finally obtaining the operation state of the regional comprehensive energy system. The calculation method can be used for analyzing the operation state of the regional comprehensive energy system, can calculate the internal operation states of various grid-connected energy devices at the same time, and provides a data basis for researching the characteristics of the system and the devices and formulating corresponding operation control strategies.