The invention discloses a transformer substation secondary circuit rapid on-off protection pressing plate, which belongs to the technical field of transformer substation safety protection and aims tosolve the problems that the existing protection pressing plate is low in use and operation efficiency, and mistaken electric shock is likely to happen due to the fact that metal pressing pieces are exposed. Two L-shaped sliding grooves are formed in the side wall of a cylinder sleeve; the horizontal section of the L-shaped sliding groove is formed in the clockwise direction from the tail end of the vertical section; the tail end of the horizontal section of the L-shaped sliding groove is provided with an ascending section extending upwards; the tail end of the ascending section is connected with a control section extending in the direction of the vertical section of the L-shaped sliding groove; a microswitch is embedded in each control section; the horizontal section of the pressing rod isarranged in the L-shaped sliding groove; the vertical section of the pressing rod is fixedly connected with the fixed end of a torsion spring; a pressure spring is arranged between the tail end of the vertical section of the pressing rod and the tail end of the vertical section of a rotating handle; the free end of the torsion spring is connected with the tail end center of the vertical section of the rotating handle; and a state indicator lamp is arranged on the horizontal section of the rotating handle. Thus, the operation safety of operators and equipment is effectively ensured.