
基本信息:
- 专利标题: 培南类化合物连续化后处理方法及装置
- 专利标题(英):Continuous aftertreatment method and device for penem type compounds
- 申请号:CN201910979214.0 申请日:2019-10-15
- 公开(公告)号:CN110627794A 公开(公告)日:2019-12-31
- 发明人: 洪浩 , 洪亮 , 陶建 , 郭金海 , 程希安 , 张岩
- 申请人: 凯莱英医药集团(天津)股份有限公司
- 申请人地址: 天津市滨海新区经济技术开发区洞庭三街6号
- 专利权人: 凯莱英医药集团(天津)股份有限公司
- 当前专利权人: 凯莱英医药集团(天津)股份有限公司
- 当前专利权人地址: 天津市滨海新区经济技术开发区洞庭三街6号
- 代理机构: 北京康信知识产权代理有限责任公司
- 代理人: 白雪
- 主分类号: C07D477/02
- IPC分类号: C07D477/02 ; C07D477/20
The invention provides a continuous aftertreatment method and device for penem type compounds. The method comprises the following steps: S1, performing continuous extraction on a crude reaction product of a penem type compound so as to obtain an extraction heavy phase and an extraction light phase; S2, performing continuous solid-liquid separation on the extraction heavy phase so as to obtain a liquid-phase outlier; S3, performing continuous pH value adjustment on the liquid-phase outlier till the pH value of the liquid-phase outlier is 6.1-6.3 so as to obtain a pH value adjusting liquid; andS4, performing continuous crystal separation treatment on the pH value adjusting liquid by using a first crystal separation solvent, so as to obtain a product of the penem type compound. When being adopted to perform aftertreatment on the crude reaction product of the penem type compound, the method has the advantages of being rapid in treatment speed and high in efficiency, in addition, in the treatment process, materials are stable in properties and low in deteriorating rate, and the yield and the purity of a target product can be well controlled.
公开/授权文献:
- CN110627794B 培南类化合物连续化后处理方法及装置 公开/授权日:2024-05-28
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D477/00 | 杂环化合物,含有1-氮杂二环 |
--------C07D477/02 | .制备 |