The invention belongs to the technical field of food processing, and particularly relates to a making method of mould preventing flour. The making method is performed in the manner that a housing, anarticle frame and a controller are arranged, wherein a high temperature chamber and a low temperature chamber are arranged in the housing, and are subjected to thermal insulation through a heat insulating plate; a first vent pipe and a second vent pipe are arranged on the upper side and the lower side of the high temperature chamber and the lower temperature chamber, of the housing; an air pump ismounted in the first vent pipe; a heating block is mounted on the upper side of the air outlet of the air pump, of the first vent pipe; a refrigerator is mounted at the middle part of the second ventpipe, of the housing; the air pump, the heating block and the refrigerator are electrically connected with the controller; and the article frame comprises a framework, pulleys and an article tank. Through cold and hot air flows, wheat is blown circularly, and bound water and mobile water contained in the wheat are separated out, so that the water content of the flour is low; and besides, a mildewproof agent is added to the flour, so that the flour can be stored for a long time without getting moldy.