基本信息:
- 专利标题： 检测(S)-(-)-3-氨基奎宁环胺二盐酸盐中对映异构体含量的方法
- 专利标题（英）：Method for detecting enantiomer content of (S)-(-)-3-amino quinuclidine cyclamine dihydrochloride
- 申请号：CN201910819249.8 申请日：2019-08-31
- 公开(公告)号：CN110455960A 公开(公告)日：2019-11-15
- 发明人： 孔令金 , 周悦芳 , 郑亮 , 陈明强 , 刘印 , 任继波 , 王孟 , 于康 , 翟民
- 申请人： 山东齐都药业有限公司
- 申请人地址： 山东省淄博市临淄区宏达路17号
- 专利权人： 山东齐都药业有限公司
- 当前专利权人： 山东齐都药业有限公司
- 当前专利权人地址： 山东省淄博市临淄区宏达路17号
- 代理机构： 青岛发思特专利商标代理有限公司
- 代理人： 耿霞
- 主分类号： G01N30/02
- IPC分类号： G01N30/02 ; G01N30/06
The invention belongs to the technical field of drug testing, and particularly relates to a method for detecting enantiomer content of (S)-(-)-3-amino quinuclidine cyclamine dihydrochloride. Accordingto the method, a series of compounds such as benzoyl halide and the like are utilized as derivatization reagents for derivatization of (S)-(-)-3-amino quinuclidine cyclamine dihydrochloride, the HPLC(high performance liquid chromatography) is adopted for detection, and the enantiomer content is calculated with an area normalization method. The method for detecting the enantiomer content of (S)-(-)-3-amino quinuclidine cyclamine dihydrochloride has higher repeatability, precision and accuracy, and has great significance for controlling quality of bulk pharmaceuticals of (S)-(-)-3-amino quinuclidine cyclamine dihydrochloride and guaranteeing medication safety. Besides, the series of compounds are utilized as the derivatization reagents, so that the cost is lower, the effect is good, and acertain economic benefit is obtained.
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N30/00 | 利用吸附作用、吸收作用或类似现象，或者利用离子交换，例如色谱法将材料分离成各个组分，来测试或分析材料 |
| --------G01N30/02 | .柱色谱法 |