The invention belongs to the technical field of storage and fresh-keeping of agricultural products, in particular relates to a fresh-keeping method of fresh fruits, and specifically relates to a fresh-keeping method of combining a compound solution containing melatonin, gibberellin and salicylic acid with liquid nitrogen fumigation. The steps are as follows: spraying fruits with the compound solution containing melatonin, gibberellin and salicylic acid one day before harvest, transferring the fruits to a closed space for short-time fumigation with liquid nitrogen after harvest, and then immediately transferring the fruits to a spontaneous controlled atmosphere packaging for low temperature storage. The compound solution containing melatonin, gibberellin and salicylic acid is combined withliquid nitrogen fumigation, thus the fresh-keeping method can not only realize sterilization and inhibit the synthesis of ethylene, but also inactivate fruit enzymes, and at the same time, and can achieve fast precooling so as to maintain the storage quality of fruits, achieves the purpose of prolonging the storage period and improving the fresh-keeping effect of fruits; and at the same time, theoperation is convenient, the efficiency is improved, the practicability is high and the application is convenient.