The invention relates to an environmental protection facility, and aims to provide an integrated biochemical treatment method for high-salt wastewater. The integrated biochemical treatment method hasthe characteristics of no need of long-term continuous dosing of salt-tolerant bacteria and good system stability. According to the technical scheme, the integrated biochemical treatment method for high-salt wastewater comprises the steps that an anaerobic tank and an facultative tank which are equipped with stirring devices and an aerobic tank with an aerating device are adopted, the anaerobic tank, the facultative tank and the aerobic tank communicate with in turn, tank water is equipped with the salt-tolerant bacteria, key activation elements and nutrients are added; the salt-tolerant bacteria are externally put in stages, or/and biochemical sludge (preferably sludge flowing back in a sedimentation tank) is used for upgrading step culture through domestication; the domestication upgrading step is 2,000mg/L-5,000mg/L; the staged external putting is that the salt-tolerant bacteria is put once at the time of increasing of the salinity, or the salt-tolerant bacteria is put once in a multiple step increasing mode; and the increasing degree of salinity single step should not exceed 0.5%, and finally a salt-tolerant biochemical system with the tolerance of salinity less than 6% is obtained.