The invention discloses a radix paeoniae rubra-cortex eucommiae leaf extract composition and an application thereof. Compared with single use of radix paeoniae rubra and single use of cortex eucommiaeleaves, compatibility of the radix paeoniae rubra and the cortex eucommiae leaves has favorable antibacterial effects, the radix paeoniae rubra and the cortex eucommiae leaves produce synergistic effects, and the restrainingantibacterial effects are better. According to the nosogenesis of gynecological inflammation, traditional Chinese medicine resources are fully utilized, the radix paeoniae rubra-cortex eucommiae leaf extraction composition as an antibacterial active component is applied to preparation of products for preventing and treating the gynecological inflammation, pharmaceuticallyconventional auxiliary materials are added through a conventional technology, through mixing, traditional Chinese medicine preparation products for clinical application are prepared, and the traditional Chinese medicine preparation products can also be added to sanitary products. The products disclosed by the invention have the efficacy of clearing heat, promoting urination, destroying parasites and relieving itching, are used for preventing and treating the gynecological inflammation of gynecological pelvic inflammation, adnexitis, vaginitis, urethritis and the like, and have the advantages of being rapid to take effect, good in bacterium restraining effects, small in side effects, convenient to use and the like.