Systems and methods are described for monitoring an individual subject and facilitating a motion regimen of the individual subject. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly configured to generate one or more sense signals based on detection of at least one of a movement of the body portion or at least one physiological parameter of the body portion during a motion regimen executed by the individual; a processor configured to receive the one or more sense signals, the processor including circuitry configured to identify a physiological state, including a pain state of the individual based on at least one of the movement of the body portion or the physiological parameter, and to compare at least one of the pain state, the at least one movement, or the physiological parameter of the body portion; and an effector operably coupled to the processor and threshold target values; and a communicator configured to effect at least one predetermined motion of the body portion corresponding to a motion regimen and optionally to generate communication signals responsive to instruction by the processor, the communication signals associated with comparison between at least one of the pain state, the movement, or the physiological parameter to threshold target values.