The invention belongs to the technical field of nuclear fuel preparation, and relates to a preparation method of a honeycomb fuel pellet. The preparation method which does not include a grinding stepsequentially comprises the following steps: (1) granulating: weighing raw material powder particles, filling a mold with the raw material powder particles, pre-pressing the raw material powder particles in a hydraulic machine, crushing a pre-pressed green body, sieving the crushed green body to obtain large particles, mixing the large particles with a binder, pouring the obtained mixture into a ball mill jar, placing grinding balls in the jar, and performing high-energy ball milling; (2) pressing: sieving the obtained ball-milled powder, filling the mold with the large particles, pressing thelarge particles, and demolding the pressed large particles to obtain a pellet pressed body; and (3) sintering: dewaxing the pellet pressed body, placing the dewaxed pellet pressed body in a burning boat, and placing and sintering the burning boat in a sintering furnace to obtain the finished honeycomb fuel pellet. The preparation method of the honeycomb fuel pellet of the invention has the advantages of realization of the production of the nuclear fuel pellet with a complicated shape by using the existing nuclear fuel production line, omission of the grinding process, increase of the production efficiency and reduction of the production cost.