The invention discloses a novel fermentation device which comprises a fermentation tank body, a vertical stirring device, an immobilized carrier and a circulation pipeline for feeding and dischargingof the fermentation tank body; a plurality of feeding nozzles are annularly arranged at the side wall of the fermentation tank body for feeding of the fermentation tank body; a discharging outlet is formed in the bottom of the fermentation tank body for discharging of the fermentation tank body; a circulation pump is arranged between the discharging outlet and the feeding nozzles and connected through the circulation pipeline to form a circulation loop, materials inside the fermentation tank body enter the circulation pipeline through the discharging outlet, under the drive of the circulationpump, and the materials enter the fermentation tank body through the feeding nozzles for circulation fermentation; the circulation pipeline is further provided with a feeding pipe and a discharging pipe, and the feeding pipe and the discharging pipe are each provided with a one-way valve; a fermented culture medium is guided into the circulation pipeline through the feeding pipe and enters the fermentation tank body through the feeding nozzles; a fermented product passes through the circulation pipeline and is discharged through the discharging pipe. The invention further provides applicationof the fermentation device for immobilized yeast fermentation preparation of ethyl alcohol.