The invention relates to the technical field of packaging, and discloses an injection packaging box with strong protection. The injection packaging box includes a placement box. The top of the placement box is arranged to be open. Multiple transverse plates and longitudinal plates are fixedly connected to the inside of the placement box. The multiple transverse plates and longitudinal plates separate the placement box into multiple placement grooves. Annular blocks are arranged in the multiple placement grooves. Four elastic ropes are symmetrically and fixedly connected to the side wall of each annular block. A fixing plate is fixedly connected to the bottom of each elastic rope. The top of each fixing plate is provided with a strip-shaped hole. A sliding rod is arranged in each strip-shaped hole. The two ends of each sliding rod is fixedly connected to the side walls of the corresponding strip-shaped hole. Two sliding blocks movably sleeve the rod wall of each sliding rod. The two ends of each of the two sliding blocks pass through the corresponding strip-shaped hole and extend outward. The injection packaging box with strong protection can limit and buffer injection bottles whenthe injection bottles are placed to prevent the problem of damage caused by collision and vibration of the injection bottles, and can be reused.