基本信息:
- 专利标题： 一种近红外响应型的载普拉克索的可降解微球制剂
- 专利标题（英）：Near-infrared responsive pramipexole-loaded degradable microsphere preparation
- 申请号：CN201910353068.0 申请日：2019-04-29
- 公开(公告)号：CN110090203A 公开(公告)日：2019-08-06
- 发明人： 李又欣 , 孙凤英 , 李爽 , 刘佳欣 , 李鸽 , 滕乐生
- 申请人： 南京锐利施生物技术有限公司
- 申请人地址： 江苏省南京市高新开发区高新路28号研发楼308室
- 专利权人： 南京锐利施生物技术有限公司
- 当前专利权人： 南京锐利施生物技术有限公司
- 当前专利权人地址： 江苏省南京市高新开发区高新路28号研发楼308室
- 代理机构： 吉林长春新纪元专利代理有限责任公司
- 代理人： 陈宏伟
- 主分类号： A61K9/50
- IPC分类号： A61K9/50 ; A61K47/34 ; A61K31/428 ; A61K41/00 ; A61P25/16
The invention discloses a near-infrared responsive pramipexole-loaded degradable microsphere preparation. The near-infrared responsive pramipexole-loaded microspheres (PRX/HGNS-PLGA MS) are prepared by using HGNS as a photothermal effect material and by a polyvinylpyrrolidone protective technology, and a near-infrared controlled-release microsphere drug delivery system is formed. Pramipexole whichis administered three times a day is optimized to be the microsphere preparation which is administered once every two weeks, and the instantaneous rapid drug release can be achieved by a near-infrared button in PD patients with sudden illness. The constructed near-infrared responsive pramipexole-loaded biodegradable microsphere preparation is an excellent drug delivery system, has good application prospect and is expected to be applied to the treatment of PD.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/50 | ..微型胶囊 |