基本信息:
- 专利标题： 一种评价烟草特有亚硝胺对动物体暴露风险的方法
- 专利标题（英）：Method for evaluating risk exposure on animal body by tobacco-specific nitrosamines
- 申请号：CN201910295444.5 申请日：2019-04-12
- 公开(公告)号：CN109991353A 公开(公告)日：2019-07-09
- 发明人： 张建勋 , 毛健 , 刘俊辉 , 孟庆华 , 冯明飞 , 赵贝贝 , 郎海磊 , 张启东 , 卢斌斌 , 王磊 , 刘珊 , 范武 , 史清照
- 申请人： 中国烟草总公司郑州烟草研究院
- 申请人地址： 河南省郑州市高新区枫杨街2号
- 专利权人： 中国烟草总公司郑州烟草研究院
- 当前专利权人： 中国烟草总公司郑州烟草研究院
- 当前专利权人地址： 河南省郑州市高新区枫杨街2号
- 代理机构： 郑州睿信知识产权代理有限公司
- 代理人： 郭佳效
- 主分类号： G01N30/88
- IPC分类号： G01N30/88
The invention relates to a method for evaluating risk exposure on an animal body by tobacco-specific nitrosamines. The method comprises the following steps: 1) detecting content of TSNAs and metabolite thereof; computing an AUC value, computing an alpha-hydroxylation coefficient according to the AUC value, and detecting content of the O6-mG and O2-POB-dT; and acquiring the yield of the representative DNA adduct according to the sum of the content values of the O6-mG and O2-POB-dT; 2) evaluating the alpha-hydroxylation metabolic degree according to the alpha-hydroxylation coefficient and the representative DNA adduct yield, and predicting the exposure risk on the animal body by the TSNAs. Through the method disclosed by the invention, the alpha-hydroxylation reaction degree in different individuals after the TSNAs is exposed can be evaluated according to the alpha-hydroxylation coefficient and the yield of the representative DNA adduct, thereby providing quantitative index for the potential exposure risk of the TSNAs.
公开/授权文献:
- CN109991353B 一种评价烟草特有亚硝胺对动物体暴露风险的方法 公开/授权日：2021-12-17