![一种消旋汉防己甲素的全合成方法](/CN/2019/1/59/images/201910297662.jpg)
基本信息:
- 专利标题: 一种消旋汉防己甲素的全合成方法
- 专利标题(英):Full-synthetic method of racemic tetrandrine
- 申请号:CN201910297662.2 申请日:2019-04-15
- 公开(公告)号:CN109942593A 公开(公告)日:2019-06-28
- 发明人: 金庆平 , 余斌 , 葛真真 , 戴艳群 , 陈宇 , 金岩 , 周鸣强 , 袁伟成
- 申请人: 浙江金华康恩贝生物制药有限公司 , 成都丽凯手性技术有限公司
- 申请人地址: 浙江省金华市婺城区金衢路288号
- 专利权人: 浙江金华康恩贝生物制药有限公司,成都丽凯手性技术有限公司
- 当前专利权人: 浙江金华康恩贝生物制药有限公司,成都丽凯手性技术有限公司
- 当前专利权人地址: 浙江省金华市婺城区金衢路288号
- 主分类号: C07D491/18
- IPC分类号: C07D491/18
The invention discloses a full-synthetic method of racemic tetrandrine, and belongs to the technical field of drug synthesis. The full-synthetic method of the racemic tetrandrine comprises the steps that a synthetic route adopts a convergence synthesis method, a 5-bromovanillin, namely a compound 1 and 3-hydroxy-4-methoxyphenylacetic acid, namely a compound 5 are taken as starting materials to obtain a compound 4 and a compound 6 respectively, then the compound 4 and the compound 6 are taken as raw materials to synthesize a compound 11, a compound 19 is synthesized from the compound 11, and finally, the compound 11 reacts with the compound 19. The full-synthetic method of the racemic tetrandrine has the advantages that the synthetic efficiency is higher, the yield is higher, and the cost is lower; the reaction conditions are milder, the operation is simple and convenient, the industrial value is higher, and a reference is provided for the full-synthetic method of optical voidness tetrandrine.
公开/授权文献:
- CN109942593B 一种消旋汉防己甲素的全合成方法 公开/授权日:2021-08-27