The invention relates to a demand side load regulation and control method for a large receiving end power grid. The method comprises two parts of pre-analysis and actual regulation and control. The pre-analysis method comprises the following steps: firstly, dividing loads of a large receiving end power grid into different types, and analyzing to obtain a part capable of participating in demand side load regulation and control; Analyzing a part capable of participating in demand side load regulation and control in various loads, and dividing the part into 1-n levels of loads; Dividing the same-level load in the large receiving-end power grid into the same logic partition; The actual regulation and control method comprises the steps that when a fault occurs in a large receiving end power grid, the fault level is firstly judged, the first-level load to the m-level load are regulated and controlled according to the fault level, the higher the fault level is, the larger the m is, and then aregulation and control instruction is directly issued to a logic partition corresponding to the first-level load to the m-level load or is indirectly issued through a load aggregator. The load regulation and control speed of the demand side can be increased, the effect of rapid regulation and control is achieved, and power grid loss is reduced.