The invention provides a method and a device for verifying a secondary virtual loop configuration file of an intelligent substation, and belongs to the field of secondary virtual loop data processingof intelligent substations. The calibration method comprises the steps of obtaining a standard CCD file in an SCD and a real-time CCD file in an IED device, constructing a reference device object according to the standard CCD file, and constructing a to-be-compared device object according to the real-time CCD file; Describing a connection line by taking an output end reference and an input end reference in the reference device object as keywords; Describing a connection line by taking an output end reference and an input end reference in the to-be-compared device object as keywords; And comparing the connection line in the reference device object with the connection line in the to-be-compared device object according to the keyword, thereby judging whether the standard CCD file is consistent with the real-time CCD file. The method has the beneficial effects that a maintainer can find out the situation that the CCD file configuration data are not matched with the actual operation data intime through the comparison result, and performs timely and effective processing according to the comparison result, so that the operation risk is reduced.