The invention relates to an anti-fake safety line, and specifically relates to a locally variable holographic logic corresponding information anti-fake safety line and a preparation method thereof. The locally variable holographic logic corresponding information anti-fake safety line comprises a plastic film layer, a two-dimensional code printed layer, a permanent mould pressing information layerand a positioning mould pressing layer which are arranged from top to bottom in sequence, wherein a locally hollowed-out printed layer and a locally aluminum-coated layer are arranged below the positioning mould pressing layer in sequence; the locally hollowed-out printed layer and the locally aluminum-coated layer contain partially variable information respectively; integral variable informationis formed after combination; a corresponding relationship exists between a two-dimensional code of the two-dimensional code printed layer and variable information; the variable information comprises variable graphical diagrams and/or variable numerical codes; a release layer is arranged between the locally hollowed-out printed layer and the locally aluminum-coated layer; and an invisible ink layer, corresponding to the locally aluminum-coated layer is arranged below the locally aluminum-coated layer. The variable information has a holographic alumite effect, a corresponding relationship existsbetween two-dimensional code information and the variable information, the anti-fake safety line is unlikely to counterfeit, simple to identify and good in anti-fake effect, and secondary use can beprevented effectively; and the preparation method is scientific and reasonable, simple and practicable.