The invention relates to the field of animal genetics and breeding and provides a production method and application of a Hu sheep hybridization matching line. The method comprises the following stepsof A, adopting pure Hu sheep (FecB gene mutation frequency is not lower than 90%) as female parents and specialized mutton sheep (Dupo sheep, Australian white sheep, Texel sheep and the like) as maleparents for producing a first hybrid generation after hybridization; B, directly selling the male sheep of the first hybrid generation as fattening sheep; C, hybridizing the female sheep in the firsthybrid generation with other individual male sheep in the specialized mutton sheep to produce commercial-generation hybrid mutton sheep, wherein both female and male commercial-generation hybrid mutton sheep are sold as fattening sheep. According to the method, the variety characteristics of high fertility of the Hu sheep and the mutton performance of the specialized mutton sheep variety are fullyutilized, and the produced fattening sheep are high in growth speed and mutton yield.