The invention provides a steel box girder suspension bridge axial lead processing method and belongs to the field of steel box girder suspension bridges. The steel box girder suspension bridge axial lead processing method comprises the following steps: after acceptance of a bridge, measuring full-bridge linear data and axial lead data of the bridge to obtain first data, and saving the first data;measuring the full-bridge linear data and the axial lead data of the bridge at regular time so as to obtain second data; comparing the second data with the first data so as to obtain an actual total gap of a transverse wind resistant support base; comparing the actual total gap of the transverse wind resistant support base with a preset total gap, when the actual total gap of the transverse wind resistant support base is greater than the preset total gap, disassembling and inspecting the transverse wind resistant support base. According to the steel box girder suspension bridge axial lead processing method, the transverse wind resistant support base can be prevented from being collided to a ground hydraulic trolley instantaneously, and disassembling and hoisting security and reliability can be ensured.