The invention belongs to the technical field of biological water-activation, and particularly discloses a biological water-activating based ultrasonic comprehensive therapeutic instrument for beauty salons. The biological water-activating based ultrasonic comprehensive therapeutic instrument comprises a first tank. A second tank and a third tank are fixedly mounted on the inner wall of the bottomof the first tank, an opening is formed in the top of the second tank, a servo motor is fixedly mounted on the inner wall of the inside of the bottom of the second tank, a rotary rod is fixedly mounted on an output shaft of the servo motor, a first belt pulley fixedly sleeves the rotary rod, a threaded rod is rotationally mounted in the second tank, a second belt pulley fixedly sleeves the threaded rod, a belt is wound between the second belt pulley and the first belt pulley, two slide plates are mounted on the threaded rod in a threaded manner, and clamp plates are fixedly mounted on the topsof the two slide plates. The biological water-activating based ultrasonic comprehensive therapeutic instrument has the advantages that the biological water-activating based ultrasonic comprehensive therapeutic instrument is high in practicality, and discomfort due to noise can be effectively reduced for people; the biological water-activating based ultrasonic comprehensive therapeutic instrumenthas biological water-activating functions, accordingly, therapeutic effects can be improved for people, and biological running devices are convenient to mount.