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基本信息:
- 专利标题: 用于抗微生物剂敏感性预测的流式细胞术数据处理
- 专利标题(英):FLOW CYTOMETRY DATA PROCESSING FOR ANTIMICROBIAL AGENT SENSIBILITY PREDICTION
- 申请号:CN201780042446.2 申请日:2017-07-06
- 公开(公告)号:CN109415755A 公开(公告)日:2019-03-01
- 发明人: M·拉姆吉特 , P·马埃 , G·卡内科 , M·沙佩尔
- 申请人: 生物梅里埃公司
- 申请人地址: 法国迈合西-兰托阿嘞
- 专利权人: 生物梅里埃公司
- 当前专利权人: 生物梅里埃公司
- 当前专利权人地址: 法国迈合西-兰托阿嘞
- 代理机构: 永新专利商标代理有限公司
- 代理人: 王健; 林晓红
- 优先权: 16178635.5 2016.07.08 EP
- 国际申请: PCT/EP2017/066900 2017.07.06
- 国际公布: WO2018/007501 EN 2018.01.11
- 进入国家日期: 2019-01-08
- 主分类号: C12Q1/18
- IPC分类号: C12Q1/18 ; G16B40/00
A method for predicting the sensibility phenotype of a test microorganism to an antimicrobial agent amongst susceptible, intermediate and resistant phenotypes, comprising a learning stage and a prediction stage. The learning stage comprises selecting a wide set of different strains having different known sensibility phenotypes determined according EUCAST or CLSI method, acquiring FCM (flow cytometry) distributions for each of said strain aliquoted in liquid samples with fluorescent markers and different concentrations of the antibiotic, and performing a learning machine computing on mono or multidimensional spaces involving feature vectors derived from the FCM acquisition to derive a prediction model of the sensibility phenotype to the antibiotic.
公开/授权文献:
- CN109415755B 用于抗微生物剂敏感性预测的流式细胞术数据处理 公开/授权日:2023-06-23