The invention discloses a medicine box, and aims to provide a sealed electronic medicine box with a separable electronic box. The electronic medicine box comprises an upper cover (1), a lower cover (2) and the electronic box (3), and a liquid crystal display (31) and keys (33) are arranged inside the electronic box (3); the upper cover (1) and the lower cover (2) are in movable connection, a plurality of drug placing grooves (21) are arranged in the lower cover (2), and the lower cover (2) is further provided with a sealing groove (22) and an installation groove (23); the upper cover (1) is inseal fit with the lower cover (2) through sealing strips in the sealing groove (22); and the electronic box (3) is arranged in the installation groove (23), and the electronic box (3) can be taken out. The electronic medicine box can be widely applied to the field of family medicine preservation.