The invention discloses a special high-temperature sterilizing device for gastroenteroscope, comprising an adhesive marking block, a metal closure cover and a prompt marking block. The circular sealing ring composed of a sealing rubber ring, a metal inner ring and a metal groove has good sealing performance. After being closed, the sealing rubber ring on the outer side of the metal inner ring seals the gap so as to prevent the internal temperature from being lost. The opening and closing handle composed of the arc-shaped metal block, the rubber soft block and the finger placing groove is moreconvenient when opening the bottom protective cover, the arc-shaped metal block of the opening and closing handle is welded on the bottom protective cover, and the bottom protective cover is fixed onthe sterilization box body through the plug connection mode, thereby facilitating the user to pull and open the bottom protective cover. The transparent protective cover composed of the plug-in cylinder and the transparent long board has good protection function through the return-type border frame. The internal transparent long board can protect the display screen of the operation controller wellthrough the plug-in and fixation of the plug-in cylinder.