The invention discloses an in-vehicle safety softening guardrail, comprising a guardrail body and an armrest, wherein the armrest is fixed on the guardrail body; the guardrail body comprises an outerframe body, an inner frame body and a partition plate. The inner frame body is fixed in the outer frame body, and the partition plate is fixed in the inner frame body. The left end edge of the outer frame is provided with a fixing bracket, and the armrest is fixed on the inner frame. The armrest comprises a vertical part, an inclined part and a horizontal part, wherein the horizontal part and thevertical part are respectively fixed at the upper and lower ends of the inclined part, and are respectively fixedly connected with the right end edge and the lower end edge of the inner frame at the horizontal part and the inclined part. As the integral guardrail structure of the invention has the advantage of stable product processing and mol, comfortable use, safety and reliability, the surfaceof the softening guardrail adopts the surface textured soft foam self-skinning molding, enhances the anti-skid function, and improves the soft comfort degree of the grip climbing.