The invention discloses spray drying equipment with cleaning function in the technical field of drying equipment. The spray drying equipment comprises a dryer, an atomizer and a warm-air pipe are respectively plugged in left and right sides of the top of the dryer, the bottom of the warm-air pipe extends to the inner cavity of the dryer to be provided with a warm-air shunt, a discharge hopper is mounted at the bottom of the dryer, an exhaust pipe is mounted on the right side of the discharge hopper, the other end of the exhaust pipe extends out of the outer wall of the discharge hopper to be provided with a fan, the output end of the fan is provided with a wind pipe, a cleaning window is mounted on the outer wall of the front side of the dryer, and a cleaning hole is formed in the cleaningwindow. The spray drying equipment is reasonable in design, highly practical, high in drying speed and suitable for continuous mass production; by the adoption of the fan, a filter and the exhaust pipe, waste heat can be absorbed, purified and discharged, and environment pollution is prevented; by the arrangement of the cleaning hole, residues in the spray dryer can be cleaned up favorably, and product quality is improved.