The invention relates to a sealed milk powder cover. The sealed milk powder cover comprises a cover body; the cover body sleeves an opening of a milk powder tank; a cavity is formed in the cover body;a vacuumizing device and an automatic deflation device are mounted in the cavity, and are electrically connected with an electric control device; a sealing cover is arranged at the bottom of the cavity; a sealing ring is arranged in the sealing cover; the sealing ring is a flexible elastic hollow sealing ring; a concave-convex structure is arranged on the side surface of the sealing ring; an airpump in the milk powder cover is started to vacuumize the milk powder tank for permanent preservation; when the milk powder tank needs to be opened, the deflation valve is opened to relieve a vacuum state; and the sealed milk powder cover is conveniently used, and effectively solves the problem of easy wetting after opening of the milk powder tank.