基本信息:
- 专利标题： 共载紫杉醇的辣椒素前药聚合物胶束及其制备方法
- 专利标题（英）：Paclitaxel co-carried capsicin prodrug polymeric micelle and preparation method thereof
- 申请号：CN201811248818.X 申请日：2018-10-25
- 公开(公告)号：CN109044972A 公开(公告)日：2018-12-21
- 发明人： 刘艳华 , 兰杨 , 孙悦 , 杨彤 , 马学琴 , 王昊
- 申请人： 宁夏医科大学
- 申请人地址： 宁夏回族自治区银川市兴庆区胜利街1160号
- 专利权人： 宁夏医科大学
- 当前专利权人： 宁夏医科大学
- 当前专利权人地址： 宁夏回族自治区银川市兴庆区胜利街1160号
- 代理机构： 广州市一新专利商标事务所有限公司
- 代理人： 张芳
- 主分类号： A61K9/107
- IPC分类号： A61K9/107 ; A61K47/18 ; A61K47/60 ; A61K31/165 ; A61K31/337 ; A61P35/00
The invention relates to paclitaxel co-carried capsicin prodrug polymeric micelle and a preparation method thereof. The preparation method comprises the following steps: adopting a novel prodrug polymeric micelle co-carrying technique, chemically bonding an antitumor drug, namely capsicin (CAP) with hydrophilic polyethylene glycol (PEG) to form an amphipathic capsicin prodrug polymer, and carryingan antitumor drug, namely paclitaxel (PTX) by the capsicin prodrug polymer, thereby obtaining the paclitaxel co-carried capsicin prodrug polymeric micelle. By adopting the drug carrying mode, characteristics of medicinal chemical bonding of prodrug polymers and micelle physical medicine carrying are combined, and precise control on carrying ratios of combined medicines, synchronization of in-vivodelivery behaviors of the combined medicines and maximization of synergetic antitumor effects can be achieved by using a same carrier.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K9/00 | 以特殊物理形状为特征的医药配制品 |
| --------A61K9/10 | .分散液；乳剂 |
| ----------A61K9/107 | ..乳剂 |