The invention belongs to the technical field of medicine, and discloses an Aapixaban nanometer mixed suspension and a preparation method thereof. The Aapixaban belongs to novel oral anti-freezing medicine, and is clinically used for preventing and treating thrombus; the Aapixaban has poor water solubility and low seepage performance; the oral bioavailability is limited. The prepared Aapixaban nanometer mixed suspension uses a little amount of glycocholate sodium and polyvinyl lactam-polyvinyl acetate-polyethylene glycol graft copolymerization (Soluplus) as a combined sterilizingstabilizing agent; a high-pressure homogenizing method is used for preparation. The prepared nanometer suspension has the advantages that the medicine dissolution degree and the dissolution-out speed can be improved; the medicine seepage performance is improved; the oral absorption is favorably enhanced; the bioavailability is improved; the recipe process is simple and convenient; the industrialized production is easy.