基本信息:
- 专利标题： FL118氨基酸盐酸盐及其制备方法与应用
- 专利标题（英）：FL118 amino acid hydrochloride and preparation method and applications thereof
- 申请号：CN201810758019.0 申请日：2018-07-11
- 公开(公告)号：CN108822120A 公开(公告)日：2018-11-16
- 发明人： 李庆勇 , 王文超 , 夏利华 , 蔡星辰 , 周蕾蕾 , 翁琦
- 申请人： 浙江工业大学
- 申请人地址： 浙江省杭州市下城区潮王路18号浙江工业大学科技处
- 专利权人： 浙江工业大学
- 当前专利权人： 浙江工业大学
- 当前专利权人地址： 浙江省杭州市下城区潮王路18号浙江工业大学科技处
- 代理机构： 杭州天正专利事务所有限公司
- 代理人： 黄美娟; 朱思兰
- 主分类号： C07D491/22
- IPC分类号： C07D491/22 ; A61P35/00
The invention discloses FL118 amino acid hydrochloride represented by the formula (I). FL118 amino acid hydrochloride is a novel derivative, which is prepared by coupling an amino acid ligand group with FL118 and then carrying out reactions to form hydrochloride. The preparation method has the advantages that the reaction conditions are mild, the preparation method is economic and efficient, the yield is high, the production quality is good, at the same time, generated waste (wastewater, waste gas, and waste solid) is little, and the preparation method is suitable for industrial production. The provided FL118 amino acid hydrochloride has better water solubility, higher activity, higher stability, and better bioavailability. The drug administration mode can be determined conveniently. The drug administration frequency is reduced. FL118 amino acid hydrochloride can be used to prepare drugs for treating diseases related with topoisomerase I and tumors in mammals.