基本信息:
- 专利标题： 一种吉马酮氧代丁酸的制备方法
- 专利标题（英）：Preparation method of germacrone oxobutyric acid
- 申请号：CN201810454130.0 申请日：2018-05-14
- 公开(公告)号：CN108752210A 公开(公告)日：2018-11-06
- 发明人： 刘媛媛 , 吕坤志 , 南秋利 , 余璐 , 张亚安
- 申请人： 东南大学成贤学院
- 申请人地址： 江苏省南京市浦口区东大路6号
- 专利权人： 东南大学成贤学院
- 当前专利权人： 东南大学成贤学院
- 当前专利权人地址： 江苏省南京市浦口区东大路6号
- 代理机构： 北京德崇智捷知识产权代理有限公司
- 代理人： 王斌
- 主分类号： C07C69/40
- IPC分类号： C07C69/40 ; C07C67/08
The invention relates to a preparation method of germacrone oxobutyric acid. The preparation method is characterized by comprising the following step: reacting a germacrone reducing product I with substituted succinic anhydride to prepare the germacrone oxobutyric acid II. A compound II is synthesized by adopting the preparation method for the first time, the reaction condition is mild, the operation is simple, the raw material is easy to obtain, the cost is relatively low, the subsequent structure modification and transformation are facilitated since the germacrone oxobutyric acid contains along-chain carboxyl, and the preparation method has important theoretical and practical significance in developing a novel curcuma zedoaria antitumor drug.