基本信息:
- 专利标题： 一种阿莫西林胶囊杂质的检测方法
- 专利标题（英）：Amoxicillin capsule impurity detection method
- 申请号：CN201810827305.8 申请日：2018-07-25
- 公开(公告)号：CN108693292A 公开(公告)日：2018-10-23
- 发明人： 李翠芬 , 邓淑渊 , 王玮 , 王健松 , 邢盛 , 裴泽建
- 申请人： 广州白云山医药集团股份有限公司白云山制药总厂
- 申请人地址： 广东省广州市白云区同和街云祥路88号
- 专利权人： 广州白云山医药集团股份有限公司白云山制药总厂
- 当前专利权人： 广州白云山医药集团股份有限公司白云山制药总厂
- 当前专利权人地址： 广东省广州市白云区同和街云祥路88号
- 主分类号： G01N30/88
- IPC分类号： G01N30/88
The invention provides an amoxicillin capsule impurity UPLC (high performance liquid chromatography) detection method. According to the HPLC detection method, 230nm is selected as detection wavelength, phosphate buffer-acetonitrile serves as a flowing phase, gradient elution is performed, and impurities A, B, C, D, E, F, G, H, I, J and M in amoxicillin capsules can be simultaneously detected. Under chromatographic conditions, the impurities which cannot be effectively separated by a common analysis method can be effectively separated by the method, specificity is good, sensitivity is high, analysis time is short, and a large quantity of organic solvents are saved. A new choice is provided for amoxicillin capsule impurity detection and product quality control.