基本信息:
- 专利标题： 静电混纺肝素-瑞舒伐他汀钙壳芯结构纳米纤维动脉瘤覆膜支架及制备方法
- 专利标题（英）：Electrostatic blended heparin-rosuvastatin calcium shell-core structure nanofiber aneurysm covered stent and preparation method thereof
- 申请号：CN201810129205.8 申请日：2018-02-08
- 公开(公告)号：CN108686272A 公开(公告)日：2018-10-23
- 发明人： 刘佩玺 , 安庆祝 , 刘盈君 , 朱巍 , 冯文浩
- 申请人： 复旦大学附属华山医院 , 东华大学
- 申请人地址： 上海市静安区乌鲁木齐中路12号;
- 专利权人： 复旦大学附属华山医院,东华大学
- 当前专利权人： 复旦大学附属华山医院,东华大学
- 当前专利权人地址： 上海市静安区乌鲁木齐中路12号;
- 代理机构： 上海元一成知识产权代理事务所
- 代理人： 吴桂琴
- 优先权： 2017101975996 20170329 CN
- 主分类号： A61L31/02
- IPC分类号： A61L31/02 ; A61L31/10 ; A61L31/16
The invention belongs to the fields of biomedicine and a biomacromolecule material, and relates to an electrostatic blended heparin-rosuvastatin calcium shell-core structure nanofiber aneurysm coveredstent and a preparation method thereof. The stent is characterized in that an electrostatic spinning technology is employed, nanofiber blended with heparin and rosuvastatin calcium is taken as the covered stent, the covered stent is placed at back of aneurysm neck so that tumor and circulated blood flow are isolated, so that treatment is carried out, the heparin continuously released in the material has anti-thrombosis capability, the rosuvastatin calcium has non biological activity, is easy to be preserved and transport, and can continuously release a drug, and through a plurality of endothelial factor-promoted mediates, the formation of an endothelial layer is accelerated. The covered stent with a small pipe diameter is used for clinical treatment of intracranial complex aneurysms, hasthe advantage of thrombosis resistance, and is capable of promoting endothelialization performance, and has advantages of easy production, conveying and preservation.
公开/授权文献:
- CN108686272B 静电混纺肝素-瑞舒伐他汀钙壳芯结构纳米纤维动脉瘤覆膜支架及制备方法 公开/授权日：2021-04-09
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61L | 材料或物体消毒的一般方法或装置；空气的灭菌、消毒或除臭；绷带、敷料、吸收垫或外科用品的化学方面；绷带、敷料、吸收垫或外科用品的材料 |
| ------A61L31/00 | 其他外科用品的材料 |
| --------A61L31/02 | .无机材料 |