The invention discloses a multi-phase flow heterogeneous catalytic reaction device. The device comprises an upper cavity, a middle cavity, a lower cavity, a first water inlet pipeline, a second waterinlet pipeline, side walls of a solid reactor, top meshes of the solid reactor and a guide flange, wherein the bottom end of the interior of the solid reactor composed of the side walls of the solid reactor and the top meshes of the solid reactor is filled with a solid reactant catalyst; the first water inlet pipeline is arranged inside the solid reactor; and a cyclone reactor and a plurality of enhanced reactors are arranged inside the middle cavity. The multi-phase flow heterogeneous catalytic reaction device disclosed by the invention is provided with the cyclone reactor, an impact reactorand a submerged circulating impinging stream reactor, the contradiction between multi-phase flow heterogeneous mass transfer and catalytic reaction with extremely strong timeliness is solved, meanwhile, the energy is efficiently utilized, the energy loss in heterogeneous mass transfer and catalytic reaction is avoided, the energy utilization ratio is further improved and better application prospects are brought.