The invention discloses equipment for economical, environment-friendly and safe express delivery. The equipment for the economical, environment-friendly and safe express delivery is characterized in that firstly, a layered partition type frame structure is constructed to replace the original express delivery vehicle rear box; secondly, the frame is divided into a plurality of interlayers with different dimensions, and airbags capable of being simultaneously inflated and separately deflated are arranged in the interlayers. After unpacked express items are put in the interlayers, all airbags arerapidly full of gases at one time by using an air pump which is mounted in a delivery station on the express delivery vehicle so that the express items can be very well located and protected. Couriers can safely deliver the items to destinations. Folding doors are mounted on three surfaces of the four side surfaces of the equipment to be convenient for the couriers to fetch the items from different directions; in addition, the frame of the equipment can be expanded as a basic unit to adapt to different types of transporting vehicle rear boxes. The equipment for the economical, environment-friendly and safe express delivery has the significant effects that the packaging material and labor cost are greatly reduced, energy is saved, the environmental protection is promoted, the cargo distribution volume is also reduced, the cargo delivery volume of a single vehicle is increased, and the operation cost is reduced.