The invention discloses a medical device holding device. The device comprises a box body, wherein the vertical side wall of the box body is provided with a through placement groove, opposite verticalside walls of the placement groove are provided with a first sliding groove set and a second sliding groove set from top to bottom, the first sliding groove set comprises two first sliding grooves respectively located on two opposite vertical sidewalls in the placement groove, the second sliding groove set comprises two second sliding grooves respectively located on two opposite vertical sidewallsin the placement groove, one end of each first sliding groove is provided with a first opening, the first openings are located on the outer side wall of one side of the box body, one end, away from each first opening, of the corresponding second sliding groove is provided with a second opening, and the second openings are located on the outer side wall of the other side of the box body. The medical device holding device has the advantages that the structure is simple, the operation is convenient, and a number of surgical tools can be held while avoiding the influence of bump on the positionsof the surgical tools.