The invention discloses a purpose of recombinant swine IL-1 beta in medicine preparation. The purpose of the recombinant swine IL-1 beta comprises a purpose of the preparation of medicine for activating signal channels in human cells, and a purpose of preparation of medicine for increasing adhesion factors, inflammatory cytokines, chemotactic factors or tissue factors expression of the human cells. On the basis, the medicine for regulating the signal channels in the human umbilical vein endothelial cells or the downstream gene expression is provided; the active ingredients contain recombinantswine IL-1 beta. Through the study, the effects that the recombinant swine IL-1 beta can be used for increasing the expression of adhesion factors E-selectin, VCAM-1 and ICAM-1, inflammatory cytokinesIL-6, IL-1 beta and TNF-alpha, chemotactic factors MCP-1 and IL-8, and tissue factors, and can activate the NF-Kappa B or P38 signal channels are discovered, so that the swine IL-1 beta can be used as active ingredients of medicine for realizing the functions.