The invention provides a power grid topology analysis engine system and method based on a graph database. The system comprises: a grid data source acquisition module for acquiring grid data source information; a grid data source preprocessing module for converting the grid data source information into standard data information according to modeling data format requirements; a grid graph database model establishing method for establishing a grid graph database model according to the standard data information; a business analysis module for acquiring business requirements input by a user, extracting an analysis algorithm selected by a user from the business requirements, and performing topology analysis on the standard data information in the grid graph database model according to the analysis algorithm to generate analysis service results. By implementing the power grid topology analysis engine system and method based on the graph database, the system supports distributed data storage and parallel calculating frame, efficient handling for large-scale grid graph data is achieved, and the requirements of various grid topology analysis services can be met.